The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Congenital heart disease (CHD) is the most prevalent birth defect, affecting nearly 1% of live
births; the incidence of CHD is up to tenfold higher in human fetuses,. A genetic contribution …

The endosomal system is expansive and complex, characterized by swift morphological
transitions, dynamic remodeling of membrane constituents, and intracellular positioning …

The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …

Polarized cells such as epithelial cells and neurons exhibit different plasma membrane
domains with distinct protein compositions. Recent studies have shown that sorting of …

As polarized cells, neurons maintain different sets of resident plasma membrane proteins in
their axons and dendrites, which is consistent with the different roles that these neurites …

Integrin functions are controlled by regulating their affinity for ligand, and by the efficient
recycling of intact integrins through endosomes. Here we demonstrate that the Kindlin …

Since the discovery of the low-density lipoprotein receptor (LDLR) and its association with
familial hypercholesterolemia in the early 1980s, a family of structurally related proteins has …

Rationale: COMMD (copper metabolism MURR1 domain)-containing proteins are a part of
the CCC (COMMD–CCDC22 [coiled-coil domain containing 22]–CCDC93 [coiled-coil …