Fatty acids are the most efficient substrates for energy production in vertebrates and are
essential components of the lipids that form biological membranes. Synthesis of …

Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …

Lipid droplets (LDs) provide an" on-demand" source of fatty acids (FAs) that can be
mobilized in response to fluctuations in nutrient abundance. Surprisingly, the amount of LDs …

In response to inflammatory activation by pathogens, macrophages accumulate triglycerides
in intracellular lipid droplets. The mechanisms underlying triglyceride accumulation and its …

Obesity-induced insulin resistance is a major risk factor for the development of type 2
diabetes. Basal fat cell lipolysis (ie, fat cell triacylglycerol breakdown into fatty acids and …

Background NASH is one of the fastest growing liver diseases that leads to severe steatosis,
inflammation and ultimately liver injury. However, the pathophysiological mechanisms of …

Fatty acids (FAs) activate and fuel UCP1-mediated non-shivering thermogenesis (NST) in
brown adipose tissue (BAT). Release of FAs from intracellular fat stores by adipose …

Neutrophils are critical and short-lived mediators of innate immunity that require constant
replenishment. Their differentiation in the bone marrow requires extensive cytoplasmic and …

Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD)
organelles by professional storage cells called adipocytes. These lipids are mobilized …

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity,
which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein …