The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

Simple Summary O-linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational
modification (PTM) linking nutrient flux through the hexosamine biosynthetic pathway (HBP) …

Sonic hedgehog (Shh) signaling plays a critical role in regulating cerebellum development
by maintaining the physiological proliferation of granule neuron precursors (GNPs), and its …

O-GlcNAc transferase (OGT) is an X-linked gene product that is essential for normal
development of the vertebrate embryo. It catalyses the O-GlcNAc posttranslational …

Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation), a dynamic post-
translational modification (PTM), holds profound implications in controlling various cellular …

O-Linked β-N-acetylglucosamine (O-GlcNAc) is an essential, dynamic monosaccharide post-
translational modification (PTM) found on serine and threonine residues of thousands of …

Swainsonine (SW) is the primary toxin in locoweed, a poisonous plant. SW can cause
animal poisoning, affect the quality and safety of meat products and threaten human health …

Hyperglycaemia causes pancreatic β-cells to release insulin that then attaches to a specific
expression of receptor isoform and reverses high glucose concentrations. It is well known …