Plant roots communicate with microbes in a sophisticated manner through chemical
communication within the rhizosphere, thereby leading to biofilm formation of beneficial …

The inability to make broad, minimally biased measurements of a cell's proteome stands as
a major bottleneck for understanding how gene expression translates into cellular …

Single-cell proteomics has emerged as a powerful method to characterize cellular
phenotypic heterogeneity and the cell-specific functional networks underlying biological …

Metabolomics has grown into a prominent field contributing to the molecular understanding
of complex biological processes in both health and disease. Furthermore, single-cells are …

Owing to recent advances in mass spectrometry (MS), tens to hundreds of proteins, lipids,
and small molecules can be measured in single cells. The ability to characterize the …

Compositional diversity is a fundamental property in cell populations. Single‐cell analysis
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …

We advance mass spectrometry from a cell population‐averaging tool to one capable of
quantifying the expression of diverse proteins in single embryonic cells. Our instrument …

Advances of analytical methods and emerging microfluidic tools have made it possible to
investigate biological processes in living organisms in detail and reach sensitivities sufficient …

Single-cell analysis provides insights into cellular heterogeneity and dynamics of individual
cells. This Feature highlights recent developments in key analytical techniques suited for …

Although significant advances have been made in recent years, the structural elucidation of
small molecules continues to remain a challenging issue for metabolite profiling. Many …