Homocysteine is a sulfur-containing amino acid derived from the metabolism of methionine,
an essential amino acid, and is metabolized by one of two pathways: remethylation or …

Neural tube defects (NTDs) refer to a cluster of neurodevelopmental conditions associated
with failure of neural tube closure during embryonic development. Worldwide prevalence of …

Neural tube defects (NTDs) are serious congenital malformations. Excessive maternal
homocysteine (Hcy) increases the risk of NTDs, while its mechanism remains elusive. Here …

In adult systems, high homocysteine (HoCys) levels inhibit methylation reactions and can
induce apoptosis in the central nervous system. In embryos, exogenous HoCys is …

Abstract Development of the posterior neural tube (PNT) in human embryos is a complicated
process that involves both primary and secondary neurulation. Because normal …

The caudal region of the trunk was reassessed in 52 serially sectioned human embryos of
stages 8–23, 42 of which were controlled by precise graphic reconstructions. The following …

BACKGROUND: Hyperhomocysteinemia in humans is a risk factor for adverse pregnancy
outcome, especially congenital malformations. This review summarizes the studies directed …

Periconceptional folic acid supplementation can reduce the occurrence of neural tube
defects. A low folate status will result in reduced remethylation of homocysteine (Hcy) to …

BACKGROUND The importance of metabolic factors in neural tube defects (NTDs) has been
the focus of many investigations. Several authors have suggested that abnormalities in …

Maternal hyperhomocysteinemia during pregnancy is associated with increased risk of NTD
in the offspring. Our study investigated the effects of homocysteine (Hcy) on proliferation and …