It has been nearly 10 years since the completion of the first entire genome sequence of a
Leishmania parasite. Genomic and transcriptomic analyses have advanced our …

We present a review of current knowledge about mucosal leishmaniasis (ML). Although
involvement of mucous membranes is classically admitted in New World leishmaniasis …

Leishmania spp. are protozoan parasites that have two principal life cycle stages: the motile
promastigote forms that live in the alimentary tract of the sandfly and the amastigote forms …

The host immune response has a critical role not only in protection from human
leishmaniasis but also in promoting disease severity. Although candidate gene approaches …

Background Parasites of the genus Leishmania are the causative agents of leishmaniasis, a
group of diseases that range in manifestations from skin lesions to fatal visceral disease …

The use of next generation sequencing has the power to expedite the identification of drug
resistance determinants and biomarkers and was applied successfully to drug resistance …

CD8+ T lymphocytes are components of the adaptive immune response and play an
important role in protection against many viral and bacterial infections. However, their role in …

In the search for new biomarkers and therapeutic targets for infectious diseases, several
molecules have been investigated. Small RNAs, known as microRNAs (miRs), are important …

Macrophages are mononuclear phagocytes that constitute a first line of defense against
pathogens. While lethal to many microbes, they are the primary host cells of Leishmania …

Background One of the major challenges to leishmaniasis treatment is the emergence of
parasites resistant to antimony. To study differentially expressed genes associated with drug …