Gene therapy with adeno-associated virus (AAV) vectors has demonstrated safety and long-
term efficacy in a number of trials across target organs, including eye, liver, skeletal muscle …

Recombinant adeno-associated virus (rAAV) vectors are one of the most promising in vivo
gene delivery tools. Several features make rAAV vectors an ideal platform for gene transfer …

The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

The liver is a tolerogenic organ with exquisite mechanisms of immune regulation that ensure
upkeep of local and systemic immune tolerance to self and foreign antigens, but that is also …

Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular
functions including carbohydrate, lipid and protein metabolism, detoxification and immune …

Tumour microenvironment is a complex, multicellular functional compartment that,
particularly when assembled as an abundant desmoplastic reaction, may profoundly affect …

The intravenous injection of the plant lectin concanavalin A (ConA) is a widely used model
for acute immune-mediated hepatitis in mice. In contrast to several other models for acute …

Differentiation of naïve T cells into effector cells is required for optimal protection against
different classes of microbial pathogen and for the development of immune memory. Recent …

Cholangiocarcinoma (CCA) is a dismal disease which often is diagnosed at a late stage
where the tumor is locally advanced, metastatic, and, as a result, is associated with low …

The liver is an important immunological organ that controls systemic tolerance. The liver
harbors professional and unconventional antigen-presenting cells that are crucial for …