This review focuses on the remodeling of brain circuitry associated with epilepsy, particularly
in excitatory glutamate and inhibitory GABA systems, including alterations in synaptic …

Epileptogenesis is defined as the process of developing epilepsy—a disorder characterized
by recurrent seizures—following an initial insult. Seizure incidence during the human …

Whether long febrile seizures (FSs) can cause epilepsy in the absence of genetic or
acquired predisposing factors is unclear. Having established causality between long FSs …

Preclinical research has facilitated the discovery of valuable drugs for the symptomatic
treatment of epilepsy. Yet, despite these therapies, seizures are not adequately controlled in …

Febrile infection–related epilepsy syndrome (FIRES, AERRPS, or DESC) is one of the most
severe, mostly irreversible, and presumably immune-mediated epileptic encephalopathies …

Experimental prolonged febrile seizures (FS) lead to structural and molecular changes that
promote hippocampal hyperexcitability and reduce seizure threshold to further convulsants …

Epileptogenesis refers to a phenomenon in which the brain undergoes molecular and
cellular alterations after a brain‐damaging insult, which increase its excitability and …

Importance A functional area associated with the piriform cortex, termedarea tempestas, has
been implicated in animal studies as having a crucial role in modulating seizures, but similar …

Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing
an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role …

The extent that status epilepticus (SE), but also brief seizures, affects neuronal structure and
function has been the subject of much clinical and experimental research. There is a …