Abstract The discipline of Cardio-Oncology has seen tremendous growth over the past
decade. It is devoted to the cardiovascular (CV) care of the cancer patient, especially to the …

Monoclonal antibodies (mAbs) have been used in the treatment of various diseases for over
20 years and combine high specificity with generally low toxicity. Their pharmacokinetic …

ESC Guidelines e341 (1) the specific situation of the patient. In this respect, it is specified
that, unless otherwise provided for by national regulations, offlabel use of medication should …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal
tumors of the gastrointestinal tract. Neoplastic GIST cells seem to arise from a common …

The vascular endothelial growth factor (VEGF) signaling pathway (VSP) fulfills a cardinal
role in endothelial cells and its inhibition has profound cardiovascular impact. This is true not …

Hypertension is a mechanism-based toxic effect of drugs that inhibit the vascular endothelial
growth factor signaling pathway (VSP). Substantial evidence exists for managing …

Angiogenesis inhibition with sunitinib, a multitarget tyrosine kinase inhibitor of the vascular
endothelial growth factor receptor, is associated with hypertension and cardiac toxicity, of …

Severe adverse systemic drug events occur commonly as a result of treatment of cancer
patients. Nephrotoxicity of chemotherapeutic agents remains a significant complication …

Background Hypertension (HTN) is one of the most frequent side-effects of systemic
inhibition of vascular endothelial growth factor (VEGF) signaling. Its incidence and severity …