Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …

It is predicted that Japan and European Union will soon experience appreciable decreases
in their populations due to persistently low total fertility rates (TFR) below replacement level …

BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

Ancestral environmental exposures such as toxicants, abnormal nutrition or stress can
promote the epigenetic transgenerational inheritance of disease and phenotypic variation …

The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

Background Developmental programming of the embryo is controlled by genetic information
but also dictated by epigenetic information contained in spermatozoa. Lifestyle and …

The association between poor paternal diet, perturbed embryonic development, and adult
offspring ill health represents a new focus for the Developmental Origins of Health and …

Obesity has been recognized to increase the risk of such diseases as cardiovascular
diseases, diabetes, and cancer. It indicates that obesity can impact genome stability …

Epidemiological studies suggest that a father's diet can influence offspring health. A
proposed mechanism for paternal transmission of environmental information is via the …