Fibroblast growth factor receptors (FGFRs) are aberrantly activated through single-
nucleotide variants, gene fusions and copy number amplifications in 5–10% of all human …

Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for developing first-in-class drug. A variety …

The emergence of the clustered regularly interspaced short palindromic repeats
(CRISPR)/CRISPR-associated protein 9 (Cas9) genome-editing system has brought about a …

Molecular targeted therapy has revolutionized the landscape of cancer treatment due to
better therapeutic responses and less systemic toxicity. However, therapeutic resistance is a …

Drug development (target identification, advancing drug leads to candidates for preclinical
and clinical studies) can be facilitated by genetic and genomic knowledge. Here, we review …

CRISPR-Cas9 is rapidly entering molecular biology and biomedicine as a promising gene-
editing tool. A unique feature of CRISPR-Cas9 is a single-guide RNA directing a Cas9 …

Dysregulation of the epigenome due to alterations in chromatin modifier proteins commonly
contribute to malignant transformation. To interrogate the roles of epigenetic modifiers in …

Oncogenic activation of the fibroblast growth factor receptor (FGFR) through mutations and
fusions of the FGFR gene occur in a variety of different malignancies such as urothelial …

Tyrosine phosphorylation is one of the most important posttranslational modifications in
bacteria, linked to regulating growth, migration, virulence, secondary metabolites, biofilm …

Gastric cancer is the subject of clinical and basic studies due to its high incidence and
mortality rates worldwide. Due to the diagnosis occurring in advanced stages and the classic …