Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational …

R Khera, MJ Schuemie, Y Lu, A Ostropolets, RJ Chen… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Therapeutic options for type 2 diabetes mellitus (T2DM) have expanded over
the last decade with the emergence of cardioprotective novel agents, but without such data …

Use of CHADS2 and CHA2DS2-VASc scores to predict prognosis after stroke

BK Vitturi, RJ Gagliardi - Revue neurologique, 2020 - Elsevier
Introduction Stroke is one of the most devastating neurological disorders. Currently, we don't
have an ideal score that predicts the prognosis of stroke patients. The CHADS 2 and CHA 2 …

[HTML][HTML] A predictive analytics model for differentiating between transient ischemic attacks (TIA) and its mimics

A Stanciu, M Banciu, A Sadighi, KA Marshall… - BMC medical informatics …, 2020 - Springer
Background Transient ischemic attack (TIA) is a brief episode of neurological dysfunction
resulting from cerebral ischemia not associated with permanent cerebral infarction. TIA is …

NOAC Therapy According to CHA2DS2-VASc Without Atrial Fibrillation: A Systematic Review

R Maddalena - Cardiology in Review, 2023 - journals.lww.com
Abstract According to Quality-Adjusted Life Expectancy, novel oral anticoagulant therapy is
preferred when the stroke risk is higher than 0.9% per year. CHA 2 DS 2-VASc is a tool to …

[HTML][HTML] Prediction of aneurysmal subarachnoid hemorrhage in comparison with other stroke types using routine care data

JP Kanning, HJA van Os, M Rakers, MJH Wermer… - Plos one, 2024 - journals.plos.org
Aneurysmal subarachnoid hemorrhage (aSAH) can be prevented by early detection and
treatment of intracranial aneurysms in high-risk individuals. We investigated whether …

Mortality and stroke recurrence in a rehabilitation cohort of patients with cerebral infarcts and Chagas disease

VVA Montanaro, TF Hora, CM da Silva… - European …, 2018 - karger.com
Background: Chagas disease is related to ischemic stroke (IS), although few
epidemiological studies have evaluated the associated mortality and recurrence. Our …

DARE-ISC model for prediction of 1-year ischaemic stroke risk in the general population and atrial fibrillation patients: a Danish nationwide cohort study

M Bruun-Jensen, S Winther, SE Schmidt, CM Dahl - BMJ open, 2024 - bmjopen.bmj.com
Objectives To develop a risk assessment model (DAnish REgister Ischaemic Stroke
Classifier, DARE-ISC) for predicting 1-year primary ischaemic stroke/systemic embolism …

Design and synthesis of nanoscaled IQCA-TAVV as a delivery system capable of antiplatelet activation, targeting arterial thrombus and releasing IQCA

J Wu, H Zhu, G Yang, J He, Y Wang… - International Journal …, 2018 - Taylor & Francis
Background Arterial thrombosis has been associated with a series of pathological
conditions, and the discovery of arterial thrombosis inhibitor is of clinical importance …

[HTML][HTML] Enriching the study population for ischemic stroke therapeutic trials using a machine learning algorithm

J Maharjan, Y Ektefaie, L Ryan, S Mataraso… - Frontiers in …, 2022 - frontiersin.org
Background Strokes represent a leading cause of mortality globally. The evolution of
developing new therapies is subject to safety and efficacy testing in clinical trials, which …

RESEARCH PROTOCOL: Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus

R Khera, MJ Scheumie, Y Lu, A Ostropolets, R Chen… - medRxiv, 2021 - medrxiv.org
Background Therapeutic options for type 2 diabetes mellitus (T2DM) have expanded over
the last decade with the emergence of sodium-glucose co-transporter-2 (SGLT2) inhibitors …