Dengue viral infection has become an increasing global health concern with over two-fifths
of the world's population at risk of infection. It is the most rapidly spreading vector borne …

Recombinant proteins are gaining enormous importance these days due to their wide
application as biopharmaceutical products and proven safety record. Various recombinant …

Dengue viruses (DENV) are the etiological agents of dengue fever (DF) and dengue
hemorrhagic fever (DHF). The DENV complex consists of four closely related viruses …

The Flavivirus genus of the Flaviviridae family includes 70 enveloped single-stranded-RNA
positive-sense viruses transmitted by arthropods. Among these viruses, there are a relevant …

Dengue represents a major public health problem of growing global importance. In the
absence of specific dengue therapeutics, strategies for disease control have increasingly …

Traditionally, the four dengue virus serotypes have been associated with fever, rash, and the
more severe forms, haemorrhagic fever and shock syndrome. As our knowledge as well as …

A dengue vaccine should induce long-lasting, simultaneous protection to the four dengue
viruses while avoiding the immune enhancement of viral infection. Domain III of the dengue …

Dengue, a rapidly spreading mosquito-borne human viral disease caused by dengue virus
(DENV), is a public health concern in tropical and subtropical areas due to its expanding …

Dengue viruses are emerging mosquito-borne pathogens belonging to Flaviviridae family
which are transmitted to humans via the bites of infected mosquitoes Aedes aegypti and …

Despite many years of research, a dengue vaccine is not available, and the more advanced
live attenuated vaccine candidate in clinical trials requires multiple immunizations with long …