Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis

SM Jacob, S Lee, SH Kim, KA Sharkey… - Nature Reviews …, 2024 - nature.com
Amyotrophic lateral sclerosis (ALS) is the most common form of human motor neuron
disease. It is characterized by the progressive degeneration of upper and lower motor …

Unraveling the Heterogeneity of ALS—A Call to Redefine Patient Stratification for Better Outcomes in Clinical Trials

L Tzeplaeff, AV Jürs, C Wohnrade, AF Demleitner - Cells, 2024 - mdpi.com
Despite tremendous efforts in basic research and a growing number of clinical trials aiming
to find effective treatments, amyotrophic lateral sclerosis (ALS) remains an incurable …