Ischemic stroke is a detrimental neurological disease characterized by an irreversible infarct
core surrounded by an ischemic penumbra, a salvageable region of brain tissue. Unique …

Stroke is one of the leading causes of death and disability in the world, of which ischemia
accounts for the majority. There is growing evidence of changes in synaptic connections and …

Dynamic change of mitochondrial morphology and distribution along neuronal branches are
essential for neural circuitry formation and synaptic efficacy. However, the underlying …

Lysosomal trafficking and maturation in neurons remain poorly understood and are
unstudied in vivo despite high disease relevance. We generated neuron-specific transgenic …

Controlled release of neurotransmitters stored in synaptic vesicles (SVs) is a fundamental
process that is central to all information processing in the brain. This relies on tight coupling …

The neuronal ceroid lipofuscinoses (NCL) are a group of disorders defined by shared
clinical and pathological features, including seizures and progressive decline in vision …

Neurons, because of their elaborate morphology and the long distances between distal
axons and the soma as well as their longevity, pose special challenges to autophagy and to …

Cathepsins (CTSs) are ubiquitously expressed proteases normally found in the
endolysosomal compartment where they mediate protein degradation and turnover …

The endolysosomal system is present in all cell types. Within these cells, it performs a series
of essential roles, such as trafficking and sorting of membrane cargo, intracellular signaling …

About two thirds of the patients affected with lysosomal storage diseases (LSD) experience
neurological manifestations, such as developmental delay, seizures, or psychiatric …