BACKGROUND Fibrinogen is a large (340 kDa) hexameric glycoprotein expressed by
hepatocytes. 1 Fibrinogen is encoded by 3 different genes (FGA, FGB, and FGG) and …

Introduction The rare coagulation disorders may present significant difficulties in diagnosis
and management. In addition, considerable inter‐individual variation in bleeding phenotype …

Congenital fibrinogen disorders can be quantitative (afibrinogenemia, hypofibrinogenemia)
or functional (dysfibrinognemia). To date, several genetic variants have been identified in …

Fibrinogen is a complex protein playing a major role in coagulation. Congenital
afibrinogenemia, characterized by the complete absence of fibrinogen, is associated with …

Congenital fibrinogen disorders or CFDs are heterogenous, both in clinical manifestation
and array of culprit molecular lesions. Correlations between phenotype and genotype …

Introduction The inherited bleeding disorders (IBD) community has witnessed significant
therapeutic advances recently, yet important gaps persist, particularly for those with rare …

Hereditary fibrinogen disorders (HFD) are rare coagulation disorders. Even if the spectrum
of symptoms is broad depending on the sub‐type, bleeding is the most common …

Dear Editors, we had read with a great interest the paper written by Lim et al., published in a
recent issue of the journal with title: Global coagulation assays—is there a role in thrombosis …

This guidance document was prepared on behalf of the International Council for
Standardization in Haematology (ICSH), the aim of which is to provide hemostasis-related …

Background This research aims to compare fibrinogen results, obtained from the Clauss and
PT-derived method on the Cobas t511 analyzer, in patients with specific categories of …