Novel insights into double-stranded RNA-mediated immunopathology
R de Reuver, J Maelfait - Nature Reviews Immunology, 2024 - nature.com
Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …
The competitive landscape of the dsRNA world
KA Cottrell, RJ Andrews, BL Bass - Molecular Cell, 2024 - cell.com
The ability to sense and respond to infection is essential for life. Viral infection produces
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
Abstract Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells.
Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we …
Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we …
In search of critical dsRNA targets of ADAR1
Recent studies have underscored the pivotal role of adenosine-to-inosine RNA editing,
catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by …
catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by …
Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity
Chronic and aberrant nucleic acid sensing causes type I IFN–driven autoimmune diseases,
designated type I interferonopathies. We found a significant reduction of regulatory T cells …
designated type I interferonopathies. We found a significant reduction of regulatory T cells …
[HTML][HTML] Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing
Leukemia-initiating cells (LICs) are regarded as the origin of leukemia relapse and
therapeutic resistance. Identifying direct stemness determinants that fuel LIC self-renewal is …
therapeutic resistance. Identifying direct stemness determinants that fuel LIC self-renewal is …
ADAR1: from basic mechanisms to inhibitors
J Rehwinkel, P Mehdipour - Trends in Cell Biology, 2024 - cell.com
Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-
stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in …
stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in …
[HTML][HTML] An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation
K Sinigaglia, A Cherian, Q Du, V Lacovich, D Vukić… - Cell Reports, 2024 - cell.com
Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven
interferon induction, and Adar Mavs double mutants, in which interferon induction is …
interferon induction, and Adar Mavs double mutants, in which interferon induction is …
RNA editing enzymes: structure, biological functions and applications
D Zhang, L Zhu, Y Gao, Y Wang, P Li - Cell & Bioscience, 2024 - Springer
With the advancement of sequencing technologies and bioinformatics, over than 170
different RNA modifications have been identified. However, only a few of these modifications …
different RNA modifications have been identified. However, only a few of these modifications …
Navigating the landscape of epitranscriptomics and host immunity
E Huang, C Frydman, X Xiao - Genome Research, 2024 - genome.cshlp.org
RNA modifications, also termed epitranscriptomic marks, encompass chemical alterations to
individual nucleotides, including processes such as methylation and editing. These marks …
individual nucleotides, including processes such as methylation and editing. These marks …