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The present invention provides RNA-guided endonucleases, which are engineered for
expression in eukaryotic cells or embryos, and methods of using the RNA-guided …

The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence
and, together with a modifying polypeptide, provides for site-specific modification of a target …

2011-02-24 Assigned to IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
reassignment IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ASSIGNMENT …

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US9834791B2 - CRISPR-related methods and compositions with governing gRNAS -
Google Patents US9834791B2 - CRISPR-related methods and compositions with …

2014-09-16 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

(57) ABSTRACT A method of altering a eukaryotic cell is provided including transfecting the
eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the …

Methods and compositions comprising single guide RNAs targeted to an endogenous
mammalian β globin gene (HBB), gamma globin gene (HBG1), B-cell lymphoma/leukemia …

2014-03-02 Assigned to DOW AGROSCIENCES LLC reassignment DOW AGROSCIENCES
LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …