Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia
Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia
Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available
medications. Thus, understanding the neural basis of these deficits is crucial for the …
medications. Thus, understanding the neural basis of these deficits is crucial for the …
Brain-derived neurotrophic factor and neuropsychiatric disorders
AE Autry, LM Monteggia - Pharmacological reviews, 2012 - ASPET
Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central
nervous system (CNS). It is essential for the development of the CNS and for neuronal …
nervous system (CNS). It is essential for the development of the CNS and for neuronal …
Neurotrophin signalling: novel insights into mechanisms and pathophysiology
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …
of neuronal survival, growth and differentiation during development. While trophic factors are …
Cortical inhibitory neurons and schizophrenia
DA Lewis, T Hashimoto, DW Volk - Nature Reviews Neuroscience, 2005 - nature.com
Impairments in certain cognitive functions, such as working memory, are core features of
schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB …
schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB …
GABAergic interneurons shape the functional maturation of the cortex
C Le Magueresse, H Monyer - Neuron, 2013 - cell.com
From early embryonic development to adulthood, GABA release participates in the
construction of the mammalian cerebral cortex. The maturation of GABAergic …
construction of the mammalian cerebral cortex. The maturation of GABAergic …
The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders
A Cattaneo, N Cattane, V Begni, CM Pariante… - Translational …, 2016 - nature.com
Brain-derived neurotrophic factor (BDNF) regulates the survival and growth of neurons, and
influences synaptic efficiency and plasticity. The human BDNF gene consists of 11 exons …
influences synaptic efficiency and plasticity. The human BDNF gene consists of 11 exons …
Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis
MJ Green, SL Matheson, A Shepherd… - Molecular …, 2011 - nature.com
Brain-derived neurotrophic factor (BDNF) regulates the survival and growth of neurons, and
influences synaptic efficiency and plasticity. Several studies report reduced peripheral …
influences synaptic efficiency and plasticity. Several studies report reduced peripheral …
Psychosis and autism as diametrical disorders of the social brain
B Crespi, C Badcock - Behavioral and brain sciences, 2008 - cambridge.org
Autistic-spectrum conditions and psychotic-spectrum conditions (mainly schizophrenia,
bipolar disorder, and major depression) represent two major suites of disorders of human …
bipolar disorder, and major depression) represent two major suites of disorders of human …
[HTML][HTML] BDNF as a biomarker in diagnosis and evaluation of treatment for schizophrenia and depression
Schizophrenia and major depression disorders, both being of pathological synaptogenesis,
are the most common psychiatric disorders worldwide. These diseases, if not treated …
are the most common psychiatric disorders worldwide. These diseases, if not treated …