Radiation therapy‐associated toxicity: Etiology, management, and prevention

K Wang, JE Tepper - CA: a cancer journal for clinicians, 2021 - Wiley Online Library
Radiation therapy (RT) is a curative treatment for many malignancies and provides effective
palliation in patients with tumor‐related symptoms. However, the biophysical effects of RT …

National Cancer Institute workshop on proton therapy for children: considerations regarding brainstem injury

D Haas-Kogan, D Indelicato, H Paganetti… - International Journal of …, 2018 - Elsevier
Purpose Proton therapy can allow for superior avoidance of normal tissues. A widespread
consensus has been reached that proton therapy should be used for patients with curable …

Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation

J Piao, T Major, G Auyeung, E Policarpio, J Menon… - Cell stem cell, 2015 - cell.com
Radiation therapy to the brain is a powerful tool in the management of many cancers, but it is
associated with significant and irreversible long-term side effects, including cognitive decline …

Reirradiation of recurrent medulloblastoma: does clinical benefit outweigh risk for toxicity?

C Wetmore, D Herington, T Lin, A Onar‐Thomas… - Cancer, 2014 - Wiley Online Library
BACKGROUND Patients with recurrent medulloblastoma (MB) have a dismal prognosis.
There has been a reluctance to use radiation in the salvage therapy regimens for these …

Cerebral white matter fractional anisotropy and tract volume as measured by MR imaging are associated with impaired cognitive and motor function in pediatric …

SM Rueckriegel, H Bruhn, UW Thomale… - Pediatric blood & …, 2015 - Wiley Online Library
Background Disease and therapy cause brain damage and subsequent functional loss in
pediatric patients with posterior fossa tumors. Treatment‐related toxicity factors are resection …

Brainstem white matter integrity is related to loss of consciousness and postconcussive symptomatology in veterans with chronic mild to moderate traumatic brain …

L Delano-Wood, KJ Bangen, SF Sorg, AL Clark… - Brain imaging and …, 2015 - Springer
We investigated associations between DTI indices of three brainstem white matter tracts,
traumatic brain injury (TBI) injury characteristics, and postconcussive symptomatology (PCS) …

Quantitative imaging biomarkers of damage to critical memory regions are associated with post–radiation therapy memory performance in brain tumor patients

KR Tringale, TT Nguyen, R Karunamuni… - International Journal of …, 2019 - Elsevier
Purpose We used quantitative magnetic resonance imaging to prospectively analyze the
association between microstructural damage to memory-associated structures within the …

Linear energy transfer distributions in the brainstem depending on tumour location in intensity-modulated proton therapy of paediatric cancer

LF Fjæra, Z Li, KS Ytre-Hauge, LP Muren… - Acta …, 2017 - Taylor & Francis
Background: For tumours near organs at risk, there is concern about unintended increase in
biological dose from elevated linear energy transfer (LET) at the distal end of treatment …

Individualized map of white matter pathways: connectivity-based paradigm for neurosurgical planning

B Tunç, M Ingalhalikar, D Parker, J Lecoeur… - …, 2016 - journals.lww.com
BACKGROUND: Advances in white matter tractography enhance neurosurgical planning
and glioma resection, but white matter tractography is limited by biological variables such as …

Long-term supratentorial brain structure and cognitive function following cerebellar tumour resections in childhood

T Moberget, S Andersson, T Lundar… - Neuropsychologia, 2015 - Elsevier
The cerebellum is connected to extensive regions of the cerebrum, and cognitive deficits
following cerebellar lesions may thus be related to disrupted cerebello-cerebral connectivity …