Onco‐multi‐OMICS approach: a new frontier in cancer research
The acquisition of cancer hallmarks requires molecular alterations at multiple levels
including genome, epigenome, transcriptome, proteome, and metabolome. In the past …
including genome, epigenome, transcriptome, proteome, and metabolome. In the past …
The DNA methylation landscape of advanced prostate cancer
Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …
methylation landscape of metastatic cancer has never been defined. Through whole …
Artificial intelligence to decode cancer mechanism: beyond patient stratification for precision oncology
The multitude of multi-omics data generated cost-effectively using advanced high-
throughput technologies has imposed challenging domain for research in Artificial …
throughput technologies has imposed challenging domain for research in Artificial …
Molecular evolution of early-onset prostate cancer identifies molecular risk markers and clinical trajectories
Identifying the earliest somatic changes in prostate cancer can give important insights into
tumor evolution and aids in stratifying high-from low-risk disease. We integrated whole …
tumor evolution and aids in stratifying high-from low-risk disease. We integrated whole …
Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
M Arechederra, F Daian, A Yim, SK Bazai… - Nature …, 2018 - nature.com
Epigenetic modifications such as aberrant DNA methylation reshape the gene expression
repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) …
repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) …
Increased serine and one-carbon pathway metabolism by PKCλ/ι deficiency promotes neuroendocrine prostate cancer
Increasingly effective therapies targeting the androgen receptor have paradoxically
promoted the incidence of neuroendocrine prostate cancer (NEPC), the most lethal subtype …
promoted the incidence of neuroendocrine prostate cancer (NEPC), the most lethal subtype …
Random forest-based modelling to detect biomarkers for prostate cancer progression
R Toth, H Schiffmann, C Hube-Magg, F Büscheck… - Clinical …, 2019 - Springer
Background The clinical course of prostate cancer (PCa) is highly variable, demanding an
individualized approach to therapy. Overtreatment of indolent PCa cases, which likely do not …
individualized approach to therapy. Overtreatment of indolent PCa cases, which likely do not …
SPOP mutation induces DNA methylation via stabilizing GLP/G9a
Mutations in SPOP E3 ligase gene are reportedly associated with genome-wide DNA
hypermethylation in prostate cancer (PCa) although the underlying mechanisms remain …
hypermethylation in prostate cancer (PCa) although the underlying mechanisms remain …
Integration of gene expression and DNA methylation data across different experiments
Y Itai, N Rappoport, R Shamir - Nucleic Acids Research, 2023 - academic.oup.com
Integrative analysis of multi-omic datasets has proven to be extremely valuable in cancer
research and precision medicine. However, obtaining multimodal data from the same …
research and precision medicine. However, obtaining multimodal data from the same …
What do we have to know about PD-L1 expression in prostate cancer? A systematic literature review. Part 1: Focus on immunohistochemical results with discussion of …
A Palicelli, M Bonacini, S Croci, C Magi-Galluzzi… - Cells, 2021 - mdpi.com
Immunotherapy targeting the PD-1–PD-L1 axis yielded good results in treating different
immunologically ''hot''tumors. A phase II study revealed good therapeutic activity of …
immunologically ''hot''tumors. A phase II study revealed good therapeutic activity of …