The central nervous system is not a static, hard-wired organ. Examples of neuroplasticity,
whether at the level of the synapse, the cell, or within and between circuits, can be found …

This review is based on a lecture presented at the Craig H. Neilsen Foundation sponsored
Spinal Cord Injury Training Program at Ohio State University. We discuss the advantages …

Dysfunctional breathing is the main cause of morbidity and mortality after traumatic injury of
the cervical spinal cord, and often necessitates assisted ventilation, thus stressing the need …

Respiratory compromise after cervical spinal cord injury (SCI) is a leading cause of mortality
and morbidity. Most SCIs are incomplete, and spinal respiratory motoneurons as well as …

The specific roles that different types of neurons play in recovery from injury is poorly
understood. Here, we show that increasing the excitability of ipsilaterally projecting …

Ampakines are positive allosteric modulators of AMPA receptors. We hypothesized that low-
dose ampakine treatment increases diaphragm electromyogram (EMG) activity after mid …

The neuromotor control of the diaphragm muscle (DIAm) involves motor unit recruitment,
sustained activity (incrementing and decrementing), and motor unit derecruitment, phases …

High spinal cord injuries (SCI) lead to permanent respiratory insufficiency, and the search for
new therapeutics to restore this function is essential. To date, the most documented …

Abstract Activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors increases phrenic motor output. Ampakines are a class of drugs that are positive …

The present study was designed to evaluate the therapeutic effectiveness and mechanism of
acute intermittent hypoxia on respiratory function at distinct injury stages following mid …