The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …

Abstract The RNA polymerase II (Pol II) enzyme transcribes all protein-coding and most non-
coding RNA genes and is globally regulated by Mediator—a large, conformationally flexible …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

Complex organisms require tissue-specific transcriptional programs, yet little is known about
how these are established. The transcription factor FoxA1 is thought to contribute to gene …

The metal-responsive transcription factor-1 (MTF-1, also termed MRE-binding transcription
factor-1 or metal regulatory transcription factor-1) is a pluripotent transcriptional regulator …

Cellular homeostasis requires transcriptional outputs to be coordinated, and many events
post-transcription initiation can dictate the levels and functions of mature transcripts. To …

Gene expression is regulated by genomic enhancers that recruit transcription factors and
cofactors to activate transcription from target core promoters. Over the past years, thousands …

Transcription factors with aberrant activity in disease are promising yet untested targets for
therapeutic development, particularly in oncology. Directly inhibiting or activating the …

The regulation of divalent zinc has been observed in a wide range of organisms. Since this
metal is an essential nutrient, but also toxic in excess, zinc homeostasis is crucial for normal …

SAGA/TFTC‐type multiprotein complexes play important roles in the regulation of
transcription. We have investigated the importance of the nuclear positioning of a gene, its …