Glutamylation imbalance impairs the molecular architecture of the photoreceptor cilium
O Mercey, S Gadadhar, MM Magiera, L Lebrun… - The EMBO …, 2024 - embopress.org
Microtubules, composed of conserved α/β-tubulin dimers, undergo complex post-
translational modifications (PTMs) that fine-tune their properties and interactions with other …
translational modifications (PTMs) that fine-tune their properties and interactions with other …
NEKL-4 regulates microtubule stability and mitochondrial health in ciliated neurons
KM Power, KC Nguyen, A Silva, S Singh, DH Hall… - Journal of Cell …, 2024 - rupress.org
Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is
abundant in cilia, and its dysregulation may contribute to ciliopathies and …
abundant in cilia, and its dysregulation may contribute to ciliopathies and …
Molecular architectures of centrosomes in C. elegans embryos visualized by cryo-electron tomography
F Tollervey, MU Rios, E Zagoriy, JB Woodruff… - Developmental Cell, 2024 - cell.com
Centrosomes organize microtubules that are essential for mitotic divisions in animal cells.
They consist of centrioles surrounded by pericentriolar material (PCM). Questions related to …
They consist of centrioles surrounded by pericentriolar material (PCM). Questions related to …
Molecular characterization of MAP9 in the photoreceptor sensory cilia as a modifier in canine RPGRIP1-associated cone-rod dystrophy
K Takahashi, JC Kwok, Y Sato, GD Aguirre… - Frontiers in Cellular …, 2023 - frontiersin.org
Photoreceptors possess a highly specialized primary cilium containing expanded ciliary
membrane discs called the outer segment. The photoreceptor cilium is essential for the …
membrane discs called the outer segment. The photoreceptor cilium is essential for the …
Primary cilia as therapeutic targets
Y Nishimura, M Saito, W Otsu… - Frontiers in Molecular …, 2023 - frontiersin.org
The primary cilium is an antenna-like structure of the plasma membrane. Primary cilia
contain receptors and channels that detect extracellular signals and transduce them into the …
contain receptors and channels that detect extracellular signals and transduce them into the …
[HTML][HTML] Native molecular architectures of centrosomes in C. elegans embryos
F Tollervey, MU Rios, E Zagoriy, JB Woodruff… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Centrosomes organize microtubules that are essential for mitotic divisions in animal cells.
They consist of centrioles surrounded by Pericentriolar Material (PCM). Questions related to …
They consist of centrioles surrounded by Pericentriolar Material (PCM). Questions related to …
[HTML][HTML] NEKL-4 regulates microtubule stability and mitochondrial health in C. elegans ciliated neurons
KM Power, KC Nguyen, A Silva, S Singh, DH Hall… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is
abundant in cilia, and its dysregulation may contribute to ciliopathies and …
abundant in cilia, and its dysregulation may contribute to ciliopathies and …
A cytoskeletal scaffold promotes motile cilia assembly by regulating transition-zone integrity
H Park, M Choi, HOL Cheung, Y Zhang, S Makino… - bioRxiv, 2025 - biorxiv.org
Motile cilia are eukaryotic organelles with essential chemo-and mechano-sensing functions
across evolution, from single cell organisms to humans. Motile cilia of the mammalian …
across evolution, from single cell organisms to humans. Motile cilia of the mammalian …
イヌ遺伝性網膜変性モデルを用いた繊毛病の分子機構の研究
髙橋慶， 宮寺恵子 - 日本薬理学雑誌, 2024 - jstage.jst.go.jp
要約 ヒトは高度に発達した網膜を有し, 外部情報のおよそ 8 割を視覚から得ているため,
視覚障害が人々の日常生活に及ぼす影響は非常に大きい. 網膜の最外層に整列し光シグナルを …
視覚障害が人々の日常生活に及ぼす影響は非常に大きい. 網膜の最外層に整列し光シグナルを …