High‐throughput metabolomics by 1D NMR

A Vignoli, V Ghini, G Meoni, C Licari… - Angewandte Chemie …, 2019 - Wiley Online Library
Metabolomics deals with the whole ensemble of metabolites (the metabolome). As one of
the‐omic sciences, it relates to biology, physiology, pathology and medicine; but metabolites …

From correlation to causation: analysis of metabolomics data using systems biology approaches

A Rosato, L Tenori, M Cascante, PR De Atauri Carulla… - Metabolomics, 2018 - Springer
Introduction Metabolomics is a well-established tool in systems biology, especially in the top–
down approach. Metabolomics experiments often results in discovery studies that provide …

Serum or plasma (and which plasma), that is the question

A Vignoli, L Tenori, C Morsiani, P Turano… - Journal of proteome …, 2022 - ACS Publications
Blood derivatives are the biofluids of choice for metabolomic clinical studies since blood can
be collected with low invasiveness and is rich in biological information. However, the choice …

A comparison of serum and plasma blood collection tubes for the integration of epidemiological and metabolomics data

J Sotelo-Orozco, SY Chen, I Hertz-Picciotto… - Frontiers in molecular …, 2021 - frontiersin.org
Blood is a rich biological sample routinely collected in clinical and epidemiological studies.
With advancements in high throughput-omics technology, such as metabolomics …

Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial

M Roca, MI Alcoriza, JC Garcia-Cañaveras… - Analytica Chimica Acta, 2021 - Elsevier
Metabolomics has become an invaluable tool for both studying metabolism and biomarker
discovery. The great technical advances in analytical chemistry and bioinformatics have …

Age and sex effects on plasma metabolite association networks in healthy subjects

A Vignoli, L Tenori, C Luchinat… - Journal of proteome …, 2018 - ACS Publications
In the era of precision medicine, the analysis of simple information like sex and age can
increase the potential to better diagnose and treat conditions that occur more frequently in …

Controlling pre-analytical process in human serum/plasma metabolomics

D Chen, S Zhao, L Li, L Li - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Metabolome analysis is a key component of serum/plasma metabolomics studies for clinical
and biological applications. There are several steps involved, including pre-analytical …

Sample management for clinical biochemistry assays: Are serum and plasma interchangeable specimens?

G Lima-Oliveira, D Monneret, F Guerber… - Critical reviews in …, 2018 - Taylor & Francis
The constrained economic context leads laboratories to centralize their routine analyses on
high-throughput platforms, to which blood collection tubes are sent from peripheral sampling …

Serum concentrations of neonicotinoids and their characteristic metabolites in elderly population from South China: Association with osteoporosis

H Zhang, K Zhu, J Du, M Ou, J Hou, D Wang… - Environmental …, 2022 - Elsevier
Neonicotinoids (NEOs) are extensively applied in global agricultural production for pest
control but have adverse effects on human health. In this study, the concentrations of six …

Determination of one year stability of lipid plasma profile and comparison of blood collection tubes using UHPSFC/MS and HILIC-UHPLC/MS

D Wolrab, M Chocholoušková, R Jirásko, O Peterka… - Analytica Chimica …, 2020 - Elsevier
Abstract Effects of blood collection tubes, the time period, the sample origin, and the method
used on the lipidomic profile are investigated by ultrahigh-performance supercritical fluid …