The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F …

Senescence was classically defined as an irreversible cell cycle arrest in G1 phase (G1 exit)
triggered by eroded telomeres in aged primary cells. The molecular basis of this G1 arrest is …

Metabolic reprogramming has been proposed to be a hallmark of cancer, yet a systematic
characterization of the metabolic pathways active in transformed cells is currently lacking …

Akt, also known as protein kinase B, plays key roles in cell proliferation, survival and
metabolism. Akt hyperactivation contributes to many pathophysiological conditions …

DNA double-strand breaks are repaired by two main pathways: nonhomologous end joining
(NHEJ) and homologous recombination (HR). The choice between these pathways depends …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

p21Waf/CIP1 is a small unstructured protein that binds and inactivates cyclin-dependent
kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor …

The tumor suppressor p53 is activated by stress and leads to cellular outcomes such as
apoptosis and cell-cycle arrest. Its activation must be highly sensitive to ensure that cells …

Cancers of the breast and other tissues arise from aberrant decision-making by cells
regarding their survival or death, proliferation or quiescence, damage repair or bypass …

Levels of residual structure in disordered interaction domains determine in vitro binding
affinities, but whether they exert similar roles in cells is not known. Here, we show that …