In addition to their location at terminal positions, telomeric-like repeats are also present at
internal sites of the chromosomes (i ntrachromosomal or i nterstitial t elomeric s equences …

Tandem DNA repeats derived from the ancestral (TTAGGG) n run were first detected at
chromosome ends of the majority of living organisms, hence the name telomeric DNA …

Aging is the universal, intrinsic, genetically-controlled, evolutionarily-conserved and time-
dependent intricate biological process characterised by the cumulative decline in the …

Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …

By definition, telomeric sequences are located at the very ends or terminal regions of
chromosomes. However, several vertebrate species show blocks of (TTAGGG) n repeats …

The study of the proteins that bind to telomeric DNA in mammals has provided a deep
understanding of the mechanisms involved in chromosome-end protection. However, very …

In fishes, as in other vertebrate species, the DNA component of the telomeres consists of the
tandemly repeated TTAGGG motif. The length of the telomeric arrays in fishes ranges from 2 …

Interstitial telomeric sequences (ITSs) are present in many eukaryotic genomes and are
linked to genome instabilities and disease in humans. The mechanisms responsible for ITS …

Telomerase is expressed in the neonatal brain, in distinct regions of adult brain, and was
shown to protect developing neurons from apoptosis. Telomerase reactivation by gene …

Mutations of the breast and ovarian cancer susceptibility gene 1 (BRCA1) account for about
40–45% of hereditary breast cancer cases. Moreover, a significant fraction of sporadic (non …