Reactive oxygen species-powered cancer immunotherapy: Current status and challenges

M He, M Wang, T Xu, M Zhang, H Dai, C Wang… - Journal of Controlled …, 2023 - Elsevier
Reactive oxygen species (ROS) are crucial signaling molecules that can arouse immune
system. In recent decades, ROS has emerged as a unique therapeutic strategy for malignant …

Living leukocyte‐based drug delivery systems

Y Chen, D Qin, J Zou, X Li, XD Guo, Y Tang… - Advanced …, 2023 - Wiley Online Library
Leukocytes play a vital role in immune responses, including defending against invasive
pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the …

Glutathione‐scavenging celastrol‐Cu nanoparticles induce self‐amplified cuproptosis for augmented cancer immunotherapy

S Lu, Y Li, Y Yu - Advanced Materials, 2024 - Wiley Online Library
Cuproptosis is a novel copper‐dependent programmed cell death. The efficacy of
cuproptosis is highly dependent on intracellular copper accumulation and counteracted by a …

Multifunctional Calcium–Manganese Nanomodulator Provides Antitumor Treatment and Improved Immunotherapy via Reprogramming of the Tumor Microenvironment

G Luo, X Li, J Lin, G Ge, J Fang, W Song, GG Xiao… - ACS …, 2023 - ACS Publications
Ions play a vital role in regulating various biological processes, including metabolic and
immune homeostasis, which involves tumorigenesis and therapy. Thus, the perturbation of …

Tracing Immunological Interaction in Trimethylamine N‐Oxide Hydrogel‐Derived Zwitterionic Microenvironment During Promoted Diabetic Wound Regeneration

Z Li, L Li, M Yue, Q Peng, X Pu, Y Zhou - Advanced Materials, 2024 - Wiley Online Library
The diabetic wound healing is challenging due to the sabotaged delicate balance of
immune regulation via an undetermined pathophysiological mechanism, so it is crucial to …

Genetically Engineered‐Cell‐Membrane Nanovesicles for Cancer Immunotherapy

Q Cheng, Y Kang, B Yao, J Dong, Y Zhu… - Advanced …, 2023 - Wiley Online Library
The advent of immunotherapy has marked a new era in cancer treatment, offering significant
clinical benefits. Cell membrane as drug delivery materials has played a crucial role in …

Precisely inhibiting excessive intestinal epithelial cell apoptosis to efficiently treat inflammatory bowel disease with oral pifithrin‐α embedded nanomedicine (OPEN)

M Wang, Q Huang, M Liu, T Zhao, X Song… - Advanced …, 2023 - Wiley Online Library
The increased incidence of inflammatory bowel disease (IBD) has seriously affected the life
quality of patients. IBD develops due to excessive intestinal epithelial cell (IEC) apoptosis …

The emergence of cancer sono-immunotherapy

Y Yang, Y Cheng, L Cheng - Trends in Immunology, 2024 - cell.com
Owing to its remarkable ease of use, ultrasound has recently been explored for stimulating
or amplifying immune responses during cancer therapy, termed 'sono-immunotherapy' …

Multifunctional mesoporous silica nanoparticles for biomedical applications

B Xu, S Li, R Shi, H Liu - Signal Transduction and Targeted Therapy, 2023 - nature.com
Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of
nanotechnology applied in the biomedical field, due to their easily tunable structure and …

Fluorinated Titanium Oxide (TiO2–xFx) Nanospindles as Ultrasound-Triggered Pyroptosis Inducers to Boost Sonodynamic Immunotherapy

S Sun, X Huang, N Yang, H Lei, Z Pei, Z Han, L Liu… - ACS …, 2024 - ACS Publications
Pyroptosis is an inflammatory form of programmed cell death associated with the immune
system that can be induced by reactive oxygen species (ROS). As a therapeutic strategy with …