Filopodia are dynamic cell surface protrusions used for cell motility, pathogen infection, and
tissue development. The molecular mechanisms determining how and where filopodia grow …

The ability of animal cells to sense, adhere to and remodel their local extracellular matrix
(ECM) is central to control of cell shape, mechanical responsiveness, motility and signalling …

Nonmuscle myosin II (NMII) is a multimeric protein complex that generates most mechanical
force in eukaryotic cells. NMII function is controlled at three main levels. The first level …

Ductal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer. During invasion, the
encapsulating DCIS basement membrane (BM) is compromised, and tumor cells invade the …

In life sciences, tracking objects from movies enables researchers to quantify the behavior of
single particles, organelles, bacteria, cells, and even whole animals. While numerous tools …

Cadherins and integrins are intrinsically linked through the actin cytoskeleton and are
largely responsible for the mechanical integrity and organization of tissues. We show that …

The global oyster industry is severely hampered by frequent outbreaks of summer massive
mortalities. Selective breeding of disease-resistant broodstock is considered as a key …

Actin-based protrusions are at the base of many fundamental cellular processes, such as
cell adhesion, migration and intercellular communication. In recent decades, the discovery …

The myosin heavy chain 9 (MYH9) gene encodes the heavy chain of non-muscle myosin IIA
(NMIIA), which belongs to the myosin II subfamily of actin-based molecular motors. Previous …

Liver metastases still remain a major cause of colorectal cancer (CRC) patient death.
MYO10 is upregulated in several tumor types; however, its significance and the underlying …