Pathophysiological studies have extensively investigated the structural factor in
hypertension, including large and small artery remodeling and functional changes. Here, we …

Abnormalities of resistance arteries may play a role in the pathogenesis and
pathophysiology of hypertension in experimental animals and humans. Vessels that, when …

Background The heart and blood vessels are exposed to elevated blood pressure (BP) in
hypertensive patients, but their changes in response to BP or non-hemodynamic stimuli may …

Background—Altered vascular mechanics resulting from changes in collagen and integrins
may influence resistance artery structure and function and, therefore, peripheral resistance …

We have previously shown that the decrease in large artery distensibility observed in
patients with essential hypertension (HT group) was primarily due to an increase in …

Abstract Changes in vascular structure that accompany hypertension may contribute to
hypertensive end-organ damage. Both the macrovascular and microvascular levels should …

Abstract Aims Connexins (Cxs) play a role in the contractility of the aorta wall. We
investigated how connexins of the endothelial cells (ECs; Cx37, Cx40) and smooth muscle …

We hypothesized that age-linked changes in the composition and elastic properties of the
arterial wall occur earlier in hypertensive than in normotensive rats. We evaluated the …

We have recently demonstrated that in large arteries of spontaneously hypertensive rats
(SHR), there is no increase of stiffness despite the increase in wall thickness, a sign of …

In spontaneously hypertensive rats resistance artery structure, endothelial dysfunction and
geometry-independent wall stiffness were reduced by an angiotensin AT1-receptor …