Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR
releases intracellular molecules known as damage-associated molecular patterns (DAMPs) …

Atherosclerosis is a significant cardiovascular burden and a leading cause of death
worldwide, recognized as a chronic sterile inflammatory disease. Pyroptosis is a novel …

The noncanonical inflammasome, comprising inflammatory caspases 4, 5, or 11, monitors
the cytosol for bacterial lipopolysaccharide (LPS). Intracellular LPS-elicited autoproteolysis …

First recognized more than 30 years ago, glycine protects cells against rupture from diverse
types of injury. This robust and widely observed effect has been speculated to target a late …

Glioma features high fatality rate and short survival time of patients due to its fast growth
speed and high invasiveness, hence timely treatment of early‐stage glioma is extremely …

Background & Aims Liver ischemia-reperfusion (IR) injury represents a major risk factor in
both partial hepatectomy and liver transplantation. Nerve injury–induced protein 1 (Ninj1) is …

Abstract Mammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved
family of iron-sulfur cluster containing proteins and act as electron shutters between …

Abstract p53 is known to modulate metabolism and FDXR is required for steroidogenesis.
Given that FDXR is a target/regulator of p53, the FDXR–p53 axis may play a unique role in …

Background Cancer stem-like cells (CSCs) play a pivotal role in lung tumor formation and
progression. Nerve injury-induced protein 1 (Ninjurin1, Ninj1) has been implicated in lung …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) characterized by demyelination. Current treatment options for MS focus on …