Over the past 5 years, genomewide association studies have yielded a wealth of insight into
genes and chromosomal loci that contribute to susceptibility to disease. This article, the …

Genome-wide association studies (GWASs) have been heralded as a major advance in
biomedical discovery, having identified~ 2,000 robust associations with complex diseases …

The recent discovery of a new CD4+ T cell subset, Th17, has transformed our understanding
of the pathogenetic basis of an increasing number of chronic immune-mediated diseases …

All animals, including humans, live in symbiotic association with microorganisms. The
immune system accommodates host colonization by the microbiota, maintains microbiota …

Background and Aims: Interleukin 17 (IL17) is now known to be involved in a number of
chronic inflammatory disorders. However, the mechanisms regulating its production in …

Background: MicroRNAs (miRNAs) consist of a group of small noncoding RNAs that partially
regulate gene expression. We investigated the expression patterns of commonly …

Background Crohn's disease (CD) and ulcerative colitis (UC) are associated with expression
differences in genes involved in immune function, wound healing, and tissue remodeling …

Aliment Pharmacol Ther 2011; 33: 1133–1142 Summary Background Crohn's disease
incidence rates have stabilised in industrialised countries since the 1980s. Conversely, a …

Peptidoglycan recognition proteins (PGRPs or PGLYRPs) are innate immunity proteins that
are conserved from insects to mammals, recognize bacterial peptidoglycan, and function in …

It is now 5 years since the first genome-wide association studies (GWAS), published in 2005,
identified a common risk allele with large effect size for age-related macular degeneration in …