The pathophysiological mechanism underlying pregnancy complications such as congenital
malformations, miscarriage, preeclampsia, or fetal growth restriction is not entirely known …

Abstract Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy
compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is …

Lysosomal failure underlies pathogenesis of numerous congenital neurodegenerative
disorders and is an early and progressive feature of Alzheimer's disease (AD) pathogenesis …

Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual
disability, resulting from the presence of an extra complete or segment of chromosome 21 …

Mitochondrial dysfunctions critically impair nervous system development and are potentially
involved in the pathogenesis of various neurodevelopmental disorders, including Down …

Down syndrome (DS) is a genetic disease that occurs due to an aneuploidy of human
chromosome 21. Trisomy of chromosome 21 is a primary genetic cause of developmental …

Metformin, a biguanide drug, is the most commonly used first-line medication for type 2
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …

Mitochondria play a pivotal role in cellular energy-generating processes and are considered
master regulators of cell life and death fate. Mitochondrial function integrates signalling …

Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). DS is a gene
dosage disorder that results in multiple phenotypes including congenital heart defects. This …

Alterations in mitochondrial activity and morphology have been demonstrated in human
cells and tissues from individuals with Down syndrome (DS), as well as in DS mouse …