Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable
cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of …

Surgery is an important treatment modality for the majority of solid organ cancers.
Unfortunately, cancer recurrence following surgery of curative intent is common, and …

Cancer is one of the most concerning public health issues and breast cancer is one of the
most common cancers in the world. The immune cells within the tumor microenvironment …

TRPM7, a divalent cation-selective channel with kinase domains, has been widely reported
to potentially affect cancers. In this study, we conducted multiple bioinformatic analyses …

Local anesthetics are widely used during clinical cancer surgeries. Studies have suggested
that the use and the type of anesthesia affect cancer outcomes. In vivo studies and clinical …

Simple Summary The local anesthetic lidocaine suppresses some cancer cell lines but the
mechanism is unclear. Melastatin-like transient receptor potential 7 (TRPM7) ion channels …

This narrative review provides an update on the applied pharmacology of lidocaine, its
clinical scope in anaesthesia, novel concepts of analgesic and immune-modulatory effects …

As the most prevalent cancer for females, breast cancer is also the second most popular
cancer type overall. More efforts are needed to research new drugs and combination …

The divalent cation-selective channel transient receptor potential melastatin 7 (TRPM7)
channel was shown to affect the proliferation of some types of cancer cell. However, the …

Gastric cancer is one of the most the prevalent malignancies and the therapeutic strategies
for patients with gastric cancer remains limited. Local anesthetic levobupivacaine has …