Hyperthermia has demonstrated clinical success in improving the efficacy of both chemo-
and radio-therapy in solid tumors. Pre-clinical and clinical research studies have …

The complex physical and chemical reactions between the large number of low-energy (0–
30 eV) electrons (LEEs) released by high energy radiation interacting with genetic material …

This review article provides a concise overview of electron involvement in DNA radiation
damage. The review begins with the various states of radiation-produced electrons …

DNA damage induced via dissociative attachment by low-energy electrons (0 to 20 eV) is
well studied in both gas and condensed phases. However, the reactivity of ultrashort-lived …

Ionizing radiation is used in cancer radiation therapy to effectively damage the DNA of
tumors. The main damage is due to generation of highly reactive secondary species such as …

High‐energy radiation is used in combination with radiosensitizing therapeutics to treat
cancer. The most common radiosensitizers are halogenated nucleosides and cisplatin …

Background There is considerable interest in defining the metabolic abnormalities of IDH
mutant tumors to exploit for therapy. While most studies have attempted to discern function …

Reactions of radiation-produced secondary electrons (SEs) with biomacromolecules (eg,
DNA) are considered one of the primary causes of radiation-induced cell death. In this …

Radiotherapy is an invaluable tool in the treatment of cancer. However, when used as a
monotherapy, it fails to provide curative outcomes. Chemotherapy drugs are often included …

Histone proteins protect cellular DNA from radiation damage. We find that arginine, a major
component of histone proteins, protects DNA from lesions induced by low-energy secondary …