▪ Abstract DNA repair is crucial to the well-being of all organisms from unicellular life forms to
humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the …

Publisher Summary This chapter focuses on DNA polymerases (Pols) and their functions.
DNA Pols are central players in DNA repair and replication—the processes that duplicate …

Three Pol X family members have been linked to nonhomologous end joining (NHEJ) in
mammals. Template-independent TdT promotes diversity during NHEJ-dependent repair of …

DNA lesions that block replication fork progression are drivers of cancer-associated genome
alterations, but the error-prone DNA repair mechanisms acting on collapsed replication are …

Mammalian DNA polymerase μ (pol μ) is related to terminal deoxynucleotidyl transferase,
but its biological role is not yet clear. We show here that after exposure of cells to ionizing …

The X family of DNA polymerases in eukaryotic cells consists of terminal transferase, and
DNA polymerases β, λ, and μ. These enzymes have similar structural portraits, yet different …

One of the most toxic insults a cell can incur is a disruption of its linear DNA in the form of a
double‐strand break (DSB). Left unrepaired, or repaired improperly, these lesions can result …

Accurate repair of free radical-mediated DNA double-strand breaks by the nonhomologous
end joining pathway requires replacement of fragmented nucleotides in the aligned ends by …

▪ Abstract Cells have high-fidelity polymerases whose task is to accurately replicate the
genome, and low-fidelity polymerases with specialized functions. Although some of these …

The mammalian family X DNA polymerases (DNA polymerases β, λ, μ, and TdT) contribute
to base excision repair and double-strand break repair by virtue of their ability to fill short …