Traumatic brain injury (TBI) is a major health and socioeconomic problem throughout the
world. It is a complicated pathological process that consists of primary insults and a …

Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen
species (ROS) and improves nitric oxide bioavailability. It has been studied extensively in …

Despite numerous defenses, the brain is vulnerable to oxidative stress resulting from
ischemia/reperfusion. Excitotoxic stimulation of superoxide and nitric oxide production leads …

Cyclic nitroxides are a diverse group range of stable free radicals that have unique
antioxidant properties. Because of their ability to interact with free radicals, they have been …

The blood–brain barrier (BBB) has a critical role in central nervous system homeostasis.
Intercellular tight junction (TJ) protein complexes of the brain microvasculature limit …

The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS)
is a common underlying mechanism of many neuropathologies, as they have been shown to …

The blood-brain barrier (BBB) is a critical regulator of brain homeostasis. Additionally, the
BBB is the most significant obstacle to effective CNS drug delivery. It possesses specific …

Traumatic brain injury (TBI) is one of the most prevalent causes of permanent physical and
cognitive disabilities. TBI pathology results from primary insults and a multi‐mechanistic …

Traumatic brain injury (TBI) is a devastating disease, predominantely affecting young
people. Although the prognosis for TBI victims has improved in recent years, many survivors …

Cerebral ischemia occurs when blood flow to the brain is insufficient to meet metabolic
demand. This can result from cerebral artery occlusion that interrupts blood flow, limits CNS …