[HTML][HTML] A weight of evidence review of the genotoxicity of titanium dioxide (TiO2)

D Kirkland, MJ Aardema, RV Battersby… - Regulatory Toxicology …, 2022 - Elsevier
Titanium dioxide is a ubiquitous white material found in a diverse range of products from
foods to sunscreens, as a pigment and thickener, amongst other uses. Titanium dioxide has …

Genotoxicity testing of nanomaterials

R Landsiedel, N Honarvar, SB Seiffert… - Wiley …, 2022 - Wiley Online Library
Nanomaterials have outstanding and unprecedented advantageous material properties but
may also cause adverse effects in humans upon exposure. Testing nanomaterials for …

Safety assessment of titanium dioxide (E171) as a food additive

EFSA Panel on Food Additives and Flavourings … - Efsa …, 2021 - Wiley Online Library
The present opinion deals with an updated safety assessment of the food additive titanium
dioxide (E 171) based on new relevant scientific evidence considered by the Panel to be …

Advances in genotoxicity of titanium dioxide nanoparticles in vivo and in vitro

J Shi, S Han, J Zhang, Y Liu, Z Chen, G Jia - NanoImpact, 2022 - Elsevier
Abstract Titanium dioxide nanoparticles (TiO 2 NPs) are currently one of the most widely
used nanomaterials. Due to an increasing scope of applications, the exposure of humans to …

A systematic quality evaluation and review of nanomaterial genotoxicity studies: a regulatory perspective

KM Siivola, MJ Burgum, B Suárez-Merino… - Particle and fibre …, 2022 - Springer
The number of publications in the field of nanogenotoxicology and the amount of
genotoxicity data on nanomaterials (NMs) in several databases generated by European …

Assessment of the in vitro genotoxicity of TiO2 nanoparticles in a regulatory context

S Charles, S Jomini, V Fessard… - …, 2018 - Taylor & Francis
A review of in vitro genotoxicity studies on titanium dioxide nanoparticles (TiO2-NPs)
published between 2010 and 2016 was performed by France in the framework of the CLP …

Genotoxicity evaluation of titanium dioxide nanoparticles in vitro: a systematic review of the literature and meta-analysis

C Ling, H An, L Li, J Wang, T Lu, H Wang, Y Hu… - … Trace Element Research, 2021 - Springer
With the wide use of titanium dioxide nanoparticles (TiO 2-NPs), the genotoxicity of TiO 2-
NPs, which is a factor for safety assessment, has attracted people's attention. However, their …

Zirconia nanoparticles-induced toxic effects in osteoblast-like 3T3-E1 cells

M Ye, B Shi - Nanoscale Research Letters, 2018 - Springer
Zirconia (ZrO 2) is one of the widely used metal oxides for potential bio-applications such as
biosensors, cancer therapy, implants, and dentistry due to its high mechanical strength and …

In vitro cell transformation assays: a valuable approach for carcinogenic potentiality assessment of nanomaterials

N Chatterjee, E Alfaro-Moreno - International Journal of Molecular …, 2023 - mdpi.com
This review explores the application of in vitro cell transformation assays (CTAs) as a
screening platform to assess the carcinogenic potential of nanomaterials (NMs) resulting …

Multiple endpoints to evaluate pristine and remediated titanium dioxide nanoparticles genotoxicity in lung epithelial A549 cells

A Stoccoro, S Di Bucchianico, F Coppedè, J Ponti… - Toxicology letters, 2017 - Elsevier
Titanium dioxide nanoparticles (TiO 2 NP) are broadly used in a wide range of applications.
Several studies have reported that TiO 2 NP possess cytotoxic and genotoxic properties that …