Novel insights into the epigenetic control of chronic liver diseases are now emerging.
Recent advances in our understanding of the critical roles of DNA methylation, histone …

During liver organogenesis, cellular transcriptional profiles are constantly reshaped by the
action of hepatic transcriptional regulators, including FoxA1-3, GATA4/6, HNF1α/β, HNF4α …

Smyd3 is a protein methyltransferase implicated in cancer development. Here we show that
Smyd3 expression in mice is required for chemically induced liver and colon cancer …

Patients with pancreatic cancer typically develop tumor invasion and metastasis in the early
stage. These malignant behaviors might be originated from cancer stem cells (CSCs), but …

Hepatitis B virus (HBV)‐X protein (HBx) plays critical role in inducing the malignant
transformation of liver cells. Alpha fetoprotein (AFP) expression is closely related to …

Cancer stem cells (CSCs) are subpopulations of cells with stem cell characteristics that
produce both cancerous and non-tumorigenic cells in tumor tissues. The literature reports …

The recognition of intra-tumoral cellular heterogeneity has given way to the concept of the
cancer stem cell (CSC). According to this concept, CSCs are able to self-renew and …

TGF-β signaling regulates a variety of cellular processes, including proliferation, apoptosis,
differentiation, immune responses, and fibrogenesis. Here, we describe a lysine methylation …

The liver is the largest organ of the mammalian body and has the remarkable ability to fully
regenerate in order to maintain tissue homeostasis. The adult liver consists of hexagonal …

SMYD3 is a member of the SET and MYND-domain family of methyl-transferases, the
increased expression of which correlates with poor prognosis in various types of cancer. In …