The epigenome in neurodevelopmental disorders
J Reichard, G Zimmer-Bensch - Frontiers in Neuroscience, 2021 - frontiersin.org
Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …
schizophrenia, are characterized by diverse facets of neurological and psychiatric …
Emerging roles of centrosome cohesion
H Dang, E Schiebel - Open Biology, 2022 - royalsocietypublishing.org
The centrosome, consisting of centrioles and the associated pericentriolar material, is the
main microtubule-organizing centre (MTOC) in animal cells. During most of interphase, the …
main microtubule-organizing centre (MTOC) in animal cells. During most of interphase, the …
Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis
Kinesins are canonical molecular motors but can also function as modulators of intracellular
signaling. KIF26A, an unconventional kinesin that lacks motor activity, inhibits growth-factor …
signaling. KIF26A, an unconventional kinesin that lacks motor activity, inhibits growth-factor …
A glance of p53 functions in brain development, neural stem cells, and brain cancer
Y Xiong, Y Zhang, S Xiong, AE Williams-Villalobo - Biology, 2020 - mdpi.com
p53 is one of the most intensively studied tumor suppressors. It transcriptionally regulates a
broad range of genes to modulate a series of cellular events, including DNA damage repair …
broad range of genes to modulate a series of cellular events, including DNA damage repair …
An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis
Entosis is cell cannibalism utilized by tumor cells to engulf live neighboring cells for pro-or
anti-tumorigenic purposes. It is unknown whether this extraordinary cellular event can be …
anti-tumorigenic purposes. It is unknown whether this extraordinary cellular event can be …
Loss of coiled-coil protein Cep55 impairs neural stem cell abscission and results in p53-dependent apoptosis in developing cortex
To build the brain, embryonic neural stem cells (NSCs) tightly regulate their cell divisions,
undergoing a polarized form of cytokinesis that is poorly understood. Cytokinetic abscission …
undergoing a polarized form of cytokinesis that is poorly understood. Cytokinetic abscission …
Modeling human primary microcephaly with hiPSC-derived brain organoids carrying CPAP-E1235V disease-associated mutant protein
HL An, HC Kuo, TK Tang - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
The centrosome is composed of a pair of centrioles and serves as the major microtubule-
organizing center (MTOC) in cells. Centrosome dysfunction has been linked to autosomal …
organizing center (MTOC) in cells. Centrosome dysfunction has been linked to autosomal …
Tissue-wide genetic and cellular landscape shapes the execution of sequential PRC2 functions in neural stem cell lineage progression
The generation of a correctly sized cerebral cortex with all-embracing neuronal and glial cell–
type diversity critically depends on faithful radial glial progenitor (RGP) cell proliferation …
type diversity critically depends on faithful radial glial progenitor (RGP) cell proliferation …
P53 independent pathogenic mechanisms contribute to BubR1 microcephaly
NA Sterling, BK Terry, JM McDonnell… - Frontiers in Cell and …, 2023 - frontiersin.org
The mosaic variegated aneuploidy (MVA)-associated gene Budding Uninhibited by
Benzimidazole 1B (BUB1B) encodes BUBR1, a core member of the spindle assembly …
Benzimidazole 1B (BUB1B) encodes BUBR1, a core member of the spindle assembly …
[HTML][HTML] Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias
J González-Martínez, AW Cwetsch, D Martínez-Alonso… - Jci Insight, 2021 - ncbi.nlm.nih.gov
Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with
mutations in genes encoding proteins involved in centrosomal and chromosomal dynamics …
mutations in genes encoding proteins involved in centrosomal and chromosomal dynamics …