Compositions and methods for inhibiting antiapoptotic bcl-2 proteins as anti-aging agents
5,064,655 A 5,077,211 A 5,223,409 A 5,264,618 A 5,403,484 A 5,491,069 A 5,571,698 A
5,888,764 A 6,492,389 B1 6,566,495 B1 6,572,876 B2 7,939,313 B2 8,232,273 B2 …
5,888,764 A 6,492,389 B1 6,566,495 B1 6,572,876 B2 7,939,313 B2 8,232,273 B2 …
Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same
S Wang, J Chen, D McEachern, L Bai, L Liu… - US Patent …, 2016 - Google Patents
The present invention is directed to inhibitors of Bcl-2/Bcl XL, to compositions comprising the
inhibitors, and to meth ods of using the inhibitors in a therapeutic treatment of con ditions …
inhibitors, and to meth ods of using the inhibitors in a therapeutic treatment of con ditions …
Technology to inhibit vascular changes that lead to vision loss in the eye
P Tsuruda, J Hopkins, H Sweigard, Y Poon… - US Patent …, 2020 - Google Patents
This invention is based on the discovery that many eye conditions associated with aging are
mediated at least in part by cells bearing a senescent phenotype. Senescent cells …
mediated at least in part by cells bearing a senescent phenotype. Senescent cells …
用于癌症治疗的bcl-2 蛋白降解剂
郑广荣， 周道洪， 张翾 - 2024 - Google Patents
JLYAXFNOILIKPP-KXQOOQHDSA-N navitoclax Chemical compound C ([C@@ H](NC1=
CC= C (C= C1S (= O)(= O) C (F)(F) F) S (= O)(= O) NC (= O) C1= CC= C (C= C1) N1CCN …
CC= C (C= C1S (= O)(= O) C (F)(F) F) S (= O)(= O) NC (= O) C1= CC= C (C= C1) N1CCN …
Benzamide compounds
JR Pinchman, PQ Huang, KD Bunker, RK Sit… - US Patent …, 2022 - Google Patents
2020-07-07 Assigned to ZENO MANAGEMENT, INC. reassignment ZENO MANAGEMENT,
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …
Benzamide compounds
JR Pinchman, PQ Huang, KD Bunker, RK Sit… - US Patent …, 2023 - Google Patents
2020-07-07 Assigned to ZENO MANAGEMENT, INC. reassignment ZENO MANAGEMENT,
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …
Benzamide compounds
JR Pinchman, PQ Huang, KD Bunker, RK Sit… - US Patent …, 2022 - Google Patents
2020-07-07 Assigned to ZENO MANAGEMENT, INC. reassignment ZENO MANAGEMENT,
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …
Compositions and methods for selectively depleting senescent cells
Death Pathways,” The Oncologist, 2006, pp. 342-357, vol. 11. Richardson, R.,“Ionizing
radiation and aging: rejuvenating an old idea,” Aging, 2009, pp. 887-902, vol. 1. Rodier, F. et …
radiation and aging: rejuvenating an old idea,” Aging, 2009, pp. 887-902, vol. 1. Rodier, F. et …
Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof
0* OC1CCN (CC# Cc (cc2F) ccc2OCCCc2c (C (O)= O) nc (N (CCc3ccc4) Cc3c4C
(Nc3nc4ccccc4 [s] 3)= O)[s] 2) CC1 Chemical compound* OC1CCN (CC# Cc (cc2F) …
(Nc3nc4ccccc4 [s] 3)= O)[s] 2) CC1 Chemical compound* OC1CCN (CC# Cc (cc2F) …
Compounds that induce degradation of anti-apoptotic Bcl-2 family proteins and the uses thereof
US10807977B2 - Compounds that induce degradation of anti-apoptotic Bcl-2 family proteins
and the uses thereof - Google Patents US10807977B2 - Compounds that induce degradation …
and the uses thereof - Google Patents US10807977B2 - Compounds that induce degradation …