Bioprocesses are scaled up for the production of large product quantities. With larger
fermenter volumes, mixing becomes increasingly inefficient and environmental gradients get …

In fed‐batch operated industrial bioreactors, glucose‐limited feeding is commonly applied
for optimal control of cell growth and product formation. Still, microbial cells such as yeasts …

Background Microorganisms must respond to changes in their environment. Analysing the
robustness of functions (ie performance stability) to such dynamic perturbations is of great …

Commercial-scale bioreactors create an unnatural environment for microbes from an
evolutionary point of view. Mixing insufficiencies expose individual cells to fluctuating …

Rational scale-up strategies to accelerate bioprocess development, require sound
knowledge of cellular behaviour under industrial conditions. In this study, the strictly aerobic …