The human platelet as an innate immune cell: interactions between activated platelets and the complement system

O Eriksson, C Mohlin, B Nilsson, KN Ekdahl - Frontiers in immunology, 2019 - frontiersin.org
Platelets play an essential role in maintaining homeostasis in the circulatory system after an
injury by forming a platelet thrombus, but they also occupy a central node in the …

Platelet proteomes, pathways, and phenotypes as informants of vascular wellness and disease

JE Aslan - Arteriosclerosis, thrombosis, and vascular biology, 2021 - Am Heart Assoc
Platelets rapidly undergo responsive transitions in form and function to repair vascular
endothelium and mediate hemostasis. In contrast, heterogeneous platelet subpopulations …

A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology

P Akbari, D Vuckovic, L Stefanucci, T Jiang… - Nature …, 2023 - nature.com
Blood cells contain functionally important intracellular structures, such as granules, critical to
immunity and thrombosis. Quantitative variation in these structures has not been subjected …

Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles

FA Graca, A Stephan, BA Minden-Birkenmaier… - Nature …, 2023 - nature.com
Skeletal muscle regeneration involves coordinated interactions between different cell types.
Injection of platelet-rich plasma is circumstantially considered an aid to muscle repair but …

Platelets in healthy and disease states: from biomarkers discovery to drug targets identification by proteomics

E Gianazza, M Brioschi, R Baetta, A Mallia… - International journal of …, 2020 - mdpi.com
Platelets are a heterogeneous small anucleate blood cell population with a central role both
in physiological haemostasis and in pathological states, spanning from thrombosis to …

Molecular proteomics and signalling of human platelets in health and disease

J Huang, P Zhang, FA Solari, A Sickmann… - International Journal of …, 2021 - mdpi.com
Platelets are small anucleate blood cells that play vital roles in haemostasis and thrombosis,
besides other physiological and pathophysiological processes. These roles are tightly …

Platelets in pediatric and neonatal sepsis: novel mediators of the inflammatory cascade

D O'Reilly, CA Murphy, R Drew, A El-Khuffash… - Pediatric …, 2022 - nature.com
Sepsis, a dysregulated host response to infection, has been difficult to accurately define in
children. Despite a higher incidence, especially in neonates, a non-specific clinical …

Tumor-educated platelet extracellular vesicles: proteomic profiling and crosstalk with colorectal cancer cells

A Contursi, R Fullone, P Szklanna-Koszalinska… - Cancers, 2023 - mdpi.com
Simple Summary The most life-threatening events in colorectal cancer (CRC) are metastasis
and thrombosis. Platelets can play a role in these outcomes via the release of medium-sized …

Release of α-granule contents during platelet activation

CW Smith - Platelets, 2022 - Taylor & Francis
Upon activation, platelets release a plethora of factors which help to mediate their dynamic
functions in hemostasis, inflammation, wound healing, tumor metastasis and angiogenesis …

[HTML][HTML] Changes in maternal platelet physiology during gestation and their interaction with trophoblasts

D Forstner, J Guettler, M Gauster - International Journal of Molecular …, 2021 - mdpi.com
Upon activation, maternal platelets provide a source of proinflammatory mediators in the
intervillous space of the placenta. Therefore, platelet-derived factors may interfere with …