DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …

Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …

Substantial evidence now exists to support that formation of DNA G-quadruplexes (G4s) is
coupled to altered gene expression. However, approaches that allow us to probe G4s in …

Human genome function is underpinned by the primary storage of genetic information in
canonical B-form DNA, with a second layer of DNA structure providing regulatory control. I …

Satellite DNA consists of abundant tandem repeats that play important roles in cellular
processes, including chromosome segregation, genome organization and chromosome end …

Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures
called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine …

Abstract 'If G-quadruplexes form so readily in vitro, Nature will have found a way of using
them in vivo'(Statement by Aaron Klug over 30 years ago). During the last decade, four …

Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …

Quadruplex nucleic acids—helical four-stranded structures known to form from guanine-rich
nucleic acid sequences through Hoogsteen-type hydrogen bonding—were once just …

Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that
involve G-quartets linked by loop nucleotides. The structural and topological diversity of G …