Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Protein arginine methyltransferases (PRMTs) play important roles in protein methylation.
PRMT5 is the major type II arginine methyltransferase that catalyzes the transfer of two …

Simple Summary This review summarizes the current findings about the cellular roles of
protein arginine methyltransferases (PRMTs) in the formation of blood cells from stem cell …

Radioresistance is regarded as the main cause of local recurrence and distant metastasis in
non-small cell lung cancer. However, the underlying mechanisms of radioresistance …

The germinal center (GC) reaction plays an important role in generating humoral immunity
and is believed to give rise to most B-cell lymphomas. GC entry and exit are tightly regulated …

Abstract Protein arginine methyltransferase 5 (PRMT5) was discovered two decades ago.
The first decade focused on the biochemical characterization of PRMT5 as a regulator of …

Simple Summary Medulloblastoma is the most prevalent intracerebellar pediatric brain
tumor, accounting for approximately 20% of all childhood brain tumors and over 60% of …

Background: Liver cancer stem cells (LCSCs) are responsible for the initiation, progression
and chemoresistance of liver cancer. However, no agent targeting LCSC is available in the …