Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Thermogenesis by brown and beige adipose tissue, which requires activation by external
stimuli, can counter metabolic disease. Thermogenic respiration is initiated by adipocyte …

Mitochondria associate with lipid droplets (LDs) in fat-oxidizing tissues, but the functional
role of these peridroplet mitochondria (PDM) is unknown. Microscopic observation of …

Mammals have two types of thermogenic adipocytes: brown adipocytes and beige
adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to …

Brown and beige adipose tissues can dissipate chemical energy as heat through
thermogenic respiration, which requires uncoupling protein 1 (UCP1),. Thermogenesis from …

Fatty acids (FAs) activate and fuel UCP1-mediated non-shivering thermogenesis (NST) in
brown adipose tissue (BAT). Release of FAs from intracellular fat stores by adipose …

Lipid droplet (LD) lipolysis in brown adipose tissue (BAT) is generally considered to be
required for cold-induced nonshivering thermogenesis. Here, we show that mice lacking …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Non-shivering thermogenesis in brown adipose tissue is mediated by uncoupling protein 1
(UCP1), which provides a carefully regulated proton re-entry pathway across the …