Conversion of glial cells into functional neurons represents a potential therapeutic approach
for replenishing neuronal loss associated with neurodegenerative diseases and brain injury …

Astrocytes control many processes of the nervous system in health and disease, and
respond to injury quickly. Astrocytes produce neuroprotective factors in the injured brain to …

Reprogramming brain-resident glial cells into clinically relevant induced neurons (iNs) is an
emerging strategy toward replacing lost neurons and restoring lost brain functions. A …

Axon regeneration in the mammalian central nervous system (CNS) has been a long-
standing and highly challenging issue. Successful CNS axon regeneration will benefit many …

Direct reprogramming of glia into neurons is a potentially promising approach for the
replacement of neurons lost to injury or neurodegenerative disorders. Knockdown of the …

Direct reprogramming based on genetic factors resembles a promising strategy to replace
lost cells in degenerative diseases such as Parkinson's disease. For this, we developed a …

Astrocyte-to-neuron conversion is a promising avenue for neuronal replacement therapy.
Neurons are particularly dependent on mitochondrial function, but how well mitochondria …

The master neuronal transcription factor NeuroD1 can directly reprogram astrocytes into
induced neurons (iNeurons) after stroke. Using viral vectors to drive ectopic ND1 expression …

The capacity for neurogenesis in the adult mammalian brain is extremely limited and highly
restricted to a few regions, which greatly hampers neuronal regeneration and functional …

Spinal cord injury (SCI) is a serious neurological trauma that is challenging to treat. After
SCI, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes …