Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance

KC Nicolaou, CRH Hale, C Nilewski… - Chemical Society …, 2012 - pubs.rsc.org
The advent of organic synthesis and the understanding of the molecule as they occurred in
the nineteenth century and were refined in the twentieth century constitute two of the most …

The role of 1, 3-dithianes in natural product synthesis

M Yus, C Nájera, F Foubelo - Tetrahedron, 2003 - Elsevier
The normal reactivity of a carbonyl compound (I) is as an a 1-reagent (II) and the temporary
reversal of the characteristic pattern of reactivity of a functional group is described by the …

Improved electrochemical and thermal properties of nickel rich LiNi0. 6Co0. 2Mn0. 2O2 cathode materials by SiO2 coating

W Cho, SM Kim, JH Song, T Yim, SG Woo… - Journal of Power …, 2015 - Elsevier
A surface coating of SiO 2 is applied to a Ni rich LiNi 0.6 Co 0.2 Mn 0.2 O 2 cathode material
in a bid to improve its electrochemical and thermal properties. A uniform coating is achieved …

2-Furyl phosphines as ligands for transition-metal-mediated organic synthesis

NG Andersen, BA Keay - Chemical Reviews, 2001 - ACS Publications
The construction of carbon-carbon and carbonheteroatom bonds by transition-metal-
mediated organic processes has become fundamental to the science of synthetic organic …

Application of complex aldol reactions to the total synthesis of phorboxazole B

DA Evans, DM Fitch, TE Smith… - Journal of the American …, 2000 - ACS Publications
The synthesis of phorboxazole B has been accomplished in 27 linear steps and an overall
yield of 12.6%. The absolute stereochemistry of the C4− C12, C33− C38, and C13− C19 …

Selective monodeprotection of bis-silyl ethers

RD Crouch - Tetrahedron, 2004 - Elsevier
As synthetic targets have grown more complex, protection/deprotection protocols have
assumed prominent roles in synthetic organic chemistry. 1–3 The ability to efficiently protect …

From nature to the laboratory and into the clinic

KC Nicolaou, JS Chen, SM Dalby - Bioorganic & medicinal chemistry, 2009 - Elsevier
Natural products possess a broad diversity of structure and function, and they provide
inspiration for chemistry, biology, and medicine. In this review article, we highlight and place …

Exploiting hidden symmetry in natural products: Total syntheses of amphidinolides C and F

S Mahapatra, RG Carter - Journal of the American Chemical …, 2013 - ACS Publications
The total synthesis of amphidinolide C and a second-generation synthesis of amphidinolide
F have been accomplished through the use of a common intermediate to access both the C1 …

Recent advances in asymmetric synthesis of pipecolic acid and derivatives

C Kadouri-Puchot, S Comesse - Amino Acids, 2005 - Springer
This review covers the literature relating to asymmetric syntheses of pipecolic acid
derivatives from 1997 to present. This review is organized according to the position and the …

Total synthesis of rapamycin

SV Ley, MN Tackett, ML Maddess… - … A European Journal, 2009 - Wiley Online Library
Rapamycin (1) is a macrocyclic natural product, established as a potent immunosuppressant
and currently of interest to the scientific community as the framework for a series of novel …