Evaluation framework for systems models

S Braakman, P Pathmanathan… - CPT: pharmacometrics & …, 2022 - Wiley Online Library
As decisions in drug development increasingly rely on predictions from mechanistic systems
models, assessing the predictive capability of such models is becoming more important …

Two new user‐friendly methods to assess pharmacometric parameter identifiability on categorical and continuous scales

M van Noort, M Ruppert - CPT: Pharmacometrics & Systems …, 2024 - Wiley Online Library
Parameter identifiability methods assess whether the parameters of a model are uniquely
determined by the observations. While the success of a model fit can provide some …

Navigating the landscape of parameter identifiability methods: A workflow recommendation for model development

M van Noort, M Ruppert, J DeJongh… - CPT …, 2024 - Wiley Online Library
In pharmacometric modeling, it is often important to know whether the data is sufficiently rich
to identify the parameters of a proposed model. While it may be possible to assess this …