Materials engineering strategies for cancer vaccine adjuvant development

X Zhang, B Yang, Q Ni, X Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Cancer vaccines have emerged as a powerful new tool for cancer immunotherapy.
Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the …

Green regenerative hydrogel wound dressing functionalized by natural drug‐food homologous small molecule self‐assembled nanospheres

X Sun, P Jia, H Zhang, M Dong, J Wang… - Advanced Functional …, 2022 - Wiley Online Library
The goal of regenerative wound healing dressings is to restore tissue function back to
normal physiological activity and accelerate skin tissue regeneration at wound sites. The …

Amino acid sequence determines the adjuvant potency of ad-tetra-peptide hydrogel

Y Zhang, Z Hu, X Li, Y Ding, Z Zhang, X Zhang… - Biomaterials …, 2022 - pubs.rsc.org
The development of novel vaccine adjuvants is essential for the production of modern
vaccines against infectious agents and cancer. We recently reported a supramolecular …

Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile

SH Zhuo, N Noda, K Hioki, S Jin… - Journal of Medicinal …, 2023 - ACS Publications
Protein or peptide cancer vaccines usually include immune potentiators, so-called
adjuvants. However, it remains challenging to identify structurally simple, chemically …

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

C Pifferi, L Aguinagalde, A Ruiz-de-Angulo… - Chemical …, 2023 - pubs.rsc.org
The overexpression of aberrantly glycosylated tumor-associated mucin-1 (TA-MUC1) in
human cancers makes it a major target for the development of anticancer vaccines derived …

Bibliometric analysis of dendritic cell-based vaccines over the past 15 years

Z Long, Y Wu, L Zhong, J Lu, B Liu - Human Vaccines & …, 2024 - Taylor & Francis
Dendritic cells, which are crucial for inducing T-cell responses, are pivotal in current
immunotherapy strategies aiming to replenish depleted T cells within the tumor …

Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells

G Ado, N Noda, HT Vu, A Perron, AD Mahapatra… - Chemical …, 2022 - pubs.rsc.org
Phase-separated membraneless organelles or biomolecular condensates play diverse
functions in cells, however recapturing their characteristics using small organic molecules …

Phytochemical Small Molecules as Potential Anti-angiogenesis Targeted Therapy for Triple-Negative Breast Cancer

K Poh-Yen - Revista Brasileira de Farmacognosia, 2024 - Springer
Triple-negative breast cancer stands out as the most formidable subtype of breast cancer.
Currently, there is a lack of specialized treatments for this particularly invasive form of …

Formulation and evaluation of lipidized imiquimod as an effective adjuvant

W Yin, B Deng, Z Xu, H Wang, F Ma… - ACS Infectious …, 2023 - ACS Publications
Adjuvants are essential for the induction of robust immune responses against vaccine
antigens. Small-molecule TLR7 agonists hold high potential for this purpose. In this …

Matthew effect: General design strategy of ultra‐fluorogenic nanoprobes with amplified dark–bright states in aggregates

S Segawa, X Ou, T Shen, T Ryu, Y Ishii, HHY Sung… - …, 2024 - Wiley Online Library
Fluorescence imaging, a key technique in biological research, frequently utilizes fluorogenic
probes for precise imaging in living systems. Tetrazine is an effective emission quencher in …